Staff Information
DR PETER ELDER Ph.D.
Section Head, Steroid Chemistry
Phone : 03 364 0300 Ex 80877
Fax : 03 364 0889
EMail : peter.elder@cdhb.govt.nz

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The Steroid and Immunobiochemistry Laboratory at Canterbury Health Laboratories provides a comprehensive analytical service for steroid hormones and related proteins. In addition it develops monoclonal antibodies to steroid hormones and steroid related proteins for use in ELISA based assays.

Publications

  1. Livesey JH ,ELDER PA. ,Ellis MJ ,McKenzie R. ,Liley B. ,Florkowski CM
    ",Seasonal variation in vitamin D levels in the Canterbury, New Zealand population in relation to available UV radiation.
    N Z Med J. 2007;120(1262):U2733
  2. Lewis JG ,Shand BI. ,Frampton CM. ,ELDER PA.
    ",An ELISA for plasma retinol-binding protein using monoclonal and polyclonal antibodies: plasma variation in normal and insulin resistant subjects.
    Clin Biochem. 2007;40(11):828-34
  3. Lewis JG ,Mopert B. ,Shand BI. ,Doogue MP. ,Soule SG. ,Frampton CM. ,ELDER PA.
    ",Plasma variation of corticosteroid-binding globulin and sex hormone-binding globulin.
    Horm Metab Res. 2006;38(4):241-5
  4. Shand B. ,ELDER PA. ,Scott R. ,Frampton C. ,Willis J.
    ",Biovariability of plasma adiponectin.
    Clin Chem Lab Med. 2006;44(10):1264-8
  5. Lewis JG ,Bagley CJ. ,ELDER PA. ,Bachmann AW. ,Torpy DJ.
    ",Plasma free cortisol fraction reflects levels of functioning corticosteroid-binding globulin.
    Clin Chim Acta. 2005;359(1-2):189-94
  6. Lewis JG ,Nakajin S. ,OhnoS. ,Warnock A. ,Florkowski CM ,ELDER PA.
    ",Circulating levels of isoflavones and markers of 5alpha-reductase activity are higher in Japanese compared with New Zealand males: What is the role of circulating steroids in prostate disease?
    Steroids. 2005;70(14):974-9
  7. Lewis JG ,Shand BI. ,ELDER PA. ,Scott RS.
    ",Plasma sex hormone-binding globulin rather than corticosteroid-binding globulin is a marker of insulin resistance in obese adult males.
    Diabetes Obes Metab. 2004;6(4):259-63
  8. Lewis JG ,Florkowski CM ,ELDER PA. ,Hunt PJ.
    ",Rheumatoid factor and false positive sex-hormone binding globulin.
    Clin Chim Acta 2003;332(1-2):139-41
  9. Lewis MG. ,Lewis JG ,ELDER PA.
    ",An enzyme-linked immunosorbent assay for corticosteroid-binding globulin using monoclonal and polyclonal antibodies: decline in CBG following synthetic ACTH.
    Clin Chim Acta. 2003;328(1-2):121-8
  10. Lewis MG. ,Lewis JG ,ELDER PA. ,Moore GA
    ",An enzyme-linked immunosorbent assay (ELISA) for methylphenidate (Ritalin ) in urine.
    J Anal Toxicol. 2003;27(6):342-5.
  11. ELDER PA. ,Hellemans J. ,Dawson T. ,Lewis JG
    "The effect of a novel deer velvet extract on human steroid metabolism."
    NZ J Sports Med. 2003;30(3):68-72
  12. Shand BI. ,Scott RS. ,ELDER PA. ,George PM
    ",Plasma adiponectin in overweight, nondiabetic individuals with or without insulin resistance.
    Diabetes Obes Metab. 2003;5(5):349-53
  13. ELDER PA. ,Hellemans J. ,Lewis JG ,Dawson T.
    "Tribulus Terrestris ingestion: does it work?"
    NZ J Sports med. 2002;29(4):74-77
  14. Florkowski CM ,ELDER PA. ,Lewis JG ,Hunt PJ p. ,Munns PL. ,Hunter W. ,Baldwin D.
    ",Two cases of adrenal suppression following a Chinese herbal remedy: a cause for concern?
    N Z Med J. 2002;115(1153):223-4
  15. Lewis JG ,Morris JC. ,Clark BM. ,ELDER PA.
    ",The effect of isoflavone extract ingestion, as Trinovin, on plasma steroids in normal men
    Steroids. 2002;67(1):25-9
  16. Lewis JG ,McGill H. ,Patton vm. ,ELDER PA.
    ",Caution on the use of saliva measurements to monitor absorption of progesterone from transdermal creams in postmenopausal women.
    Maturitas. 2002;41(1):1-6
  17. Shand BI. ,Lewis JG ,ELDER PA. ,Agarwal M.
    ",Antihypertensive treatment and glomerular size selectivity in hypertensive patients with renal parenchymal disease and proteinuria
    Clin Nephrol. 2002;58(4):321-4
  18. Lewis JG ,ELDER PA.
    ",Abbreviated direct and indirect ELISAs: a new and simple format.
    Clin Chem. 2000;46(1):137-9
  19. Lewis JG ,Longley NJ. ,ELDER PA.
    ",Monoclonal antibodies to human sex hormone-binding globulin (SHBG): characterization and use in a simple enzyme-linked immunosorbent assay (ELISA) of SHBG in plasma.
    Steroids. 1999;64(4)_:259-65
  20. Lettink M. ,Lewis JG ,ELDER PA.
    "A monoclonal Antibody raised against amino acids 497-507 of the human estrogen receptor recognises human ataxin-2"
    J.Biochem.Mol.Biol & Biophys. 1998;2:111-119
  21. Lewis JG ,ELDER PA.
    ",Alternative ELISA for sex hormone-binding globulin in plasma.
    Clin Chem. 1998;44(9):1999
  22. Domigan NM. ,Carr AC. ,Lewis JG ,ELDER PA. ,Winterbourn CC.
    "A monoclonal antibody recognizing the chlorohydrin derivatives of oleic acid for probing hypochlorous acid involvement in tissue injury."
    Redox Report. 1997;3:111-117
  23. Lewis JG ,George PM ,ELDER PA.
    ",Plasma androsterone/epiandrosterone sulphates as markers of 5 alpha-reductase activity. Effect of finasteride in normal men
    Steroids 1997;62(8-9):632-635
  24. Lewis JG ,BasonLM. ,ELDER PA.
    "Production and characterization of monoclonal antibodies to dehydroepi-androsterone sulfate: Application to direct enzyme-linked immunosorbent assays of dehydroepiandrosterone sulfate and androsterone"
    Steroids 1996;:
  25. Lewis JG ,Manley L. ,Whitlow JC. ,ELDER PA.
    ",Re-examining steroid hormone metabolites as ovulation markers using monoclonal antibodies.
    Steroids. 1994;59(4):288-91
  26. Lewis JG ,ELDER PA.
    "Recycling ovulation markers (letter)."
    NZ Med J 1993;106:165-166
  27. Lewis JG ,Manley L. ,Whitlow JC. ,ELDER PA.
    ",Production of a monoclonal antibody to cortisol: application to a direct enzyme-linked immunosorbent assay of plasma.
    Steroids 1992;57:82-85
  28. Lewis LK. ,ELDER PA. ,Barrell GK.
    "An enzyme-linked immunosorbent assay (ELISA) for measuring prolactin levels in ovine and cervine plasma."
    NZ J Agri Research 1992;35:109-115
  29. Lewis LK. ,ELDER PA. ,Barrell GK.
    "An enzyme linked immunosorbent assay (ELISA) for plasma medroxyprogesterone acetate (MPA)."
    J Steroid Biochem Molec Biol 1992;42:179-183
  30. MacDonald SJ. ,Bodger PS. ,ELDER PA.
    "Biological cell alignment for Electrofusion."
    IEEE Proceedings. 1992;139:112-116
  31. ELDER PA. ,Manley L. ,Lewis JG
    ",Use of a monoclonal antibody to estrone-3-glucuronide in an enzyme-linked immunosorbent assay (ELISA).
    J Steroid Biochem 1990;36:439-493
  32. Lewis JG ,Clifford JK. ,ELDER PA.
    ",Monoclonal antibodies to pregnanediol-3-glucuronide: application to a direct enzyme-linked immunosorbent assay of urine.
    Steroids 1990;55:314-318
  33. Borjesson BW. ,Cauchi MN. ,Compton PJ. ,ELDER PA. ,Foo TM. ,Gramacho C. ,Hahnel R. ,et al.
    ",Sources of improvement in between laboratory variation in estrogen and progestin receptor measurement using tissue samples during the Australian Quality Assurance Programme.
    Eur J Cancer Clin Oncol. 1989;25(7):1087-93
  34. Lewis JG ,Robertson JM. ,ELDER PA.
    ",A monoclonal antibody to a 48 K antigen in oestrogen-dependent human breast cancer cells.
    J Steroid Biochem 1989;33:171-178
  35. Yeo KH. ,ELDER PA. ,Lewis JG
    ",An automated solid-phase 17 alpha-hydroxyprogesterone ELISA method using a microtitre plate.
    Ann Clinical Biochem 1988;:293-297
  36. Lewis JG ,ELDER PA.
    ",Affinity chromatography using competitive elution separates polyclonal glucocorticoid antisera into fractions of varying cross-reactivity.
    J Steroid Biochem 1988;29:191-195
  37. Ross GS. ,ELDER PA. ,McWha JA. ,Pearce D. ,Pharis RP.
    "The development of an indirect Enzyme-linked Immunosorbent assay for Abscisis Acid."
    Plant Physiol 1988;22:29-33
  38. Joyce PR. ,ELDER PA. ,Clifford JC. ,Brinded PJ. ,Donald RA.
    "Plasma 11-deoxycortisol and cortisol following dexamethasone in psychiatric patients."
    J Psychiat Res 1988;22:29-33
  39. ELDER PA. ,Yeo KH. ,Lewis JG
    ",An ELISA for 17 alpha hydroxyprogesterone.
    Steroids 1988;52:427-428
  40. Joyce PR. ,Sellman JD. ,Donald RA. ,Livesey JH ,ELDER PA.
    ",The unipolar-bipolar depressive dichotomy and the relationship between afternoon prolactin and cortisol levels.
    J Affect Disord. 1988;14(2):189-93
  41. ELDER PA. ,Yeo KH. ,Lewis JG ,Clifford JK.
    ",An enzyme-linked immunosorbent assay (ELISA) for plasma progesterone: immobilised antigen approach.
    Clin Chim Acta 1987;162:199-206
  42. Joyce PR. ,Brinded PJ. ,Sellman D. ,Donald RA. ,ELDER PA.
    "The dexamethasone suppression test in psychiatry."
    NZ Med J 1987;100:173-175
  43. Joyce PR. ,Donald RA. ,ELDER PA.
    "Individual differences in plasma cortisol changes during mania and depression."
    J Affective Disorders 1987;12:1-5
  44. Lewis JG ,Manley L. ,Townsend JC. ,ELDER PA.
    ",An enzyme-linked immunosorbent assay (ELISA) for urinary free cortisol.
    Clin Chim Acta 1986;159:205-209
  45. Robertson JM. ,Lewis JG ,ELDER PA.
    ",Separation methods in the estrogen-receptor assay: dextran-coated charcoal compared with glass fibre.
    Clin Chem 1986;32:2104-2105
  46. Lewis JG ,ELDER PA. ,Yeo KH.
    ",A monoclonal antibody to prednisone: use of enzyme-linked immunosorbent assay (ELISA) for screening and characterization of antigenic determinants.
    J Steroid Biochem 1986;25:659-693
  47. Lewis JG ,Yeo KH. ,ELDER PA.
    ",A competitive enzyme-linked immunosorbent assay for plasma 11-deoxycortisol (17,21-dihydroxy-4-pregnene-3,20-dione).
    Steroids 1986;47:365-372
  48. Lewis JG ,ELDER PA.
    ",Fractionation of cortisol antisera by immunoadsorption chromatography: characterisation and use in an enzyme-linked immunosorbent assay (ELISA).
    J Steroid Biochem 1985;22:387-385
  49. ELDER PA. ,Lewis JG
    ",An enzyme-linked immunosorbent assay (ELISA) for plasma testosterone.
    J Steroid Biochem 1985;22:635-638
  50. Lewis JG ,ELDER PA.
    ",An enzyme-linked immunosorbent assay (ELISA) for plasma cortisol.
    J Steroid Biochem 1985;22:673-676
  51. ELDER PA. ,Gaynor PT. ,Lewis JG ,Bodger PS. ,Bason LM.
    "Generation of monoclonal progesterone antibodies by electrofusion techniques."
    Bioelectrochem. Bioenerg. 1977;43:35-40
    Information last updated on 30 September 2008